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KMID : 0359319960360030565
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Korean Journal of Veterinary Research
1996 Volume.36 No. 3 p.565 ~ p.570
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Effect of lead on mitochondrial activity in rat tussues
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Abstract
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Cardiac, hepatic and renal mitochondria in rats fed lead containing diets were isolated and their activities were studied in terms of NADH oxidation.
In normal rats, cardiac and renal mitochondria had similar activities and showed activity values of higher than those in hepatic mitochondria.
Cardiac mitochondiral activities in rats fed lead containing diets were increased after 4 weeks of feeding but decreased to activity values close to normal.
Renal mitochondrial activities showed a trend of inhibition in all groups fed lead containing diets but were no differenes by feeding periods of 4 and 8 weeks.
Feeding of lead containing diets could not be attributed to any changes in the hepatic mitochondrial antivities at experimental doses during 4-8 weeks.
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